Discovery and isolation of anandamide and other endocannabinoids.
نویسنده
چکیده
منابع مشابه
The Role of the Endocannabinoids in Suppression of the Hypothalamic- pituitary-adrenal Axis Activity by Doxepin
Objective(s) The mechanism(s) by which antidepressants regulate the hypothalamic-pituitary-adrenal (HPA) axis remain elusive. The endocannabinoid system (eCBs) which exhibits antidepressant potential, appears to regulate the HPA axis activity. Therefore, we aimed to investigate the role of the eCBs in the action of doxepin including its effect on the HPA axis. Materials and Methods Male Wist...
متن کاملPharmacological and therapeutic secrets of plant and brain (endo)cannabinoids.
Research on the chemistry and pharmacology of cannabinoids and endocannabinoids has reached enormous proportions, with approximately 15,000 articles on Cannabis sativa L. and cannabinoids and over 2,000 articles on endocannabinoids. The present review deals with the history of the Cannabis sativa L. plant, its uses, constituent compounds and their biogeneses, and similarity to compounds from Ra...
متن کاملCannabinoid receptors
What are endocannabinoids? THC and WIN are examples of exogenous cannabinoid receptor ligands, but the body makes its own ligands, too, and these are referred to as endocannabinoids. Two of the best-characterized endocannabinoids are anandamide and 2-arachidonylglycerol (2AG). Other candidate endocannabinoids have been identified but which, if any, of these compounds are physiologically relevan...
متن کاملLigand-receptor signaling with endocannabinoids in preimplantation embryo development and implantation.
Although adverse effects of cannabinoids on pregnancy have been indicated for many years, the mechanisms by which they exert their actions were not clearly understood. Only recently, molecular and biochemical approaches have led to the identification of two types of cannabinoid receptors, brain-type receptors (CB1-R) and spleen-type receptors (CB2-R), which mediate cannabinoid effects. These fi...
متن کاملLipids in neural function: modulation of behavior by oral administration of endocannabinoids found in foods.
Although 9(–)-tetrahydrocannabinol (THC) is not naturally found in the body, receptors for this compound have been described in brain since 1988 [1]. These receptors were later named CB1 and a receptor subtype (CB2) has been found in immune tissues [2]. An endogenous ligand for these receptors has more recently been discovered: it is the ethanolamide of arachidonic acid and was named ‘anandami...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemistry & biodiversity
دوره 4 8 شماره
صفحات -
تاریخ انتشار 2007